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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol

7dhDESOL + NADPH + H+ → DESMOL + NADP+

Reactome: R-HSA-196402
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:46740, RHEA:46741

Inputs

7dhDESOLCHEBI:27910, C27H42O, endoplasmic reticulum membrane
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

DESMOLCHEBI:17737, C27H44O, endoplasmic reticulum membrane
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

7-dehydrocholesterol reductase activity of DHCR7 [endoplasmic reticulum membrane]EC 1.3.1.21; UniProt Q9UBM7

Literature

Molecular cloning and expression of the human delta7-sterol reductase Proc Natl Acad Sci U S A, 1998