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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space

STARD3:STARD3NL, STARD4,6:CHOL → STARD3:STARD3NL, STARD4,6 + CHOL

Reactome: R-HSA-196126
Compartment: mitochondrial outer membrane · cytosol · mitochondrial intermembrane space
Rhea: RHEA:39747

Inputs

STARD3:STARD3NL, STARD4,6:CHOLR-HSA-196124, cytosol

Outputs

STARD3:STARD3NL, STARD4,6R-HSA-196094, cytosol
CHOLCHEBI:16113, C27H46O, mitochondrial inner membrane

Catalysed by

molecular carrier activity of STAR [mitochondrial intermembrane space]UniProt P49675

Literature

The binding site specificity of STARD4 subfamily: Breaking the cholesterol paradigm Mol. Cell. Endocrinol., 2015