Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol

CHdOL + NADPH + H+ + O2 → 7dhDESOL + NADP+ + 2 H2O

Reactome: R-HSA-195664
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:34003, RHEA:34004

Inputs

CHdOLCHEBI:16290, C27H44O, endoplasmic reticulum membrane
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

7dhDESOLCHEBI:27910, C27H42O, endoplasmic reticulum membrane
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
2 H2OCHEBI:15377, H2O, cytosol

Catalysed by

C-5 sterol desaturase activity of SC5D [endoplasmic reticulum membrane]UniProt O75845

Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol

Inputs

Outputs

Catalysed by

Literature