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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)

4CZYMOL + NAD+ → ZYMONE + CO2 + H+ + NADH

Reactome: R-HSA-194718
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:33455

Inputs

4CZYMOLCHEBI:143575, C28H43O3, endoplasmic reticulum membrane
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Outputs

ZYMONECHEBI:52386, C27H42O, endoplasmic reticulum membrane
CO2CHEBI:16526, CO2, cytosol
H+CHEBI:15378, H, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol

Catalysed by

3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity of NSDHL [endoplasmic reticulum membrane]EC 1.1.1.170; UniProt Q15738

Literature

NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets Hum Mol Genet, 2003