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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Outline: reactions mostly in the mitochondrion

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4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]

4,4DMCHtOL + NADPH + H+ → 14DMLANOL + NADP+

Reactome: R-HSA-194698
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:18561, RHEA:18563

Inputs

4,4DMCHtOLCHEBI:17813, C29H46O, endoplasmic reticulum membrane
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

14DMLANOLCHEBI:18364, C29H48O, endoplasmic reticulum membrane
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

Delta14-sterol reductase activity of TM7SF2 [endoplasmic reticulum membrane]EC 1.3.1.70; UniProt O76062

Literature

Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis Biochim Biophys Acta, 2006