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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol

4MZYMOL + 3 H+ + 3 NADPH + 3 O2 → 4CZYMOL + 4 H2O + 3 NADP+

Reactome: R-HSA-194669
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:47057

Inputs

4MZYMOLCHEBI:1949, C28H46O, endoplasmic reticulum membrane
3 H+CHEBI:15378, H, cytosol
3 NADPHCHEBI:57783, C21H26N7O17P3, cytosol
3 O2CHEBI:15379, O2, cytosol

Outputs

4CZYMOLCHEBI:143575, C28H43O3, endoplasmic reticulum membrane
4 H2OCHEBI:15377, H2O, cytosol
3 NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

C-4 methylsterol oxidase activity of MSMO1 [endoplasmic reticulum membrane]EC 1.14.18.9; UniProt Q15800

Literature

Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue J Biol Chem, 1996