4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one

4C4MZYMOL + NADP+ → dh4MZYMOL + H+ + CO2 + NADPH

Reactome

R-HSA-194642

Compartment

cytosol · endoplasmic reticulum membrane

Rhea

RHEA:33448

Catalysed by

• 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity of NSDHL [endoplasmic reticulum membrane]EC 1.1.1.170; UniProt Q15738

Literature

1. NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets Hum Mol Genet, 2003