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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)

ZYMONE + NADPH + H+ → ZYMOL + NADP+

Reactome: R-HSA-194632
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:33459, RHEA:33460

Inputs

ZYMONECHEBI:52386, C27H42O, endoplasmic reticulum membrane
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

ZYMOLCHEBI:18252, C27H44O, endoplasmic reticulum membrane
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity of HSD17B7 [endoplasmic reticulum membrane]EC 1.1.1.270; UniProt P56937

Literature

Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis Mol. Endocrinol., 2003