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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol

Na+ + bile salts and acids → bile salts and acids + Na+

Reactome: R-HSA-194187
Compartment: plasma membrane
Rhea: None recorded

Inputs

Na+CHEBI:29101, Na, extracellular region
bile salts and acidsR-ALL-192483, extracellular region

Outputs

bile salts and acidsR-ALL-194156, cytosol
Na+CHEBI:29101, Na, cytosol

Catalysed by

bile acid:sodium symporter activity of SLC10A2 [plasma membrane]UniProt Q12908

Literature

Bile salt transporters: molecular characterization, function, and regulation Physiol Rev, 2003
Enterohepatic bile salt transporters in normal physiology and liver disease Gastroenterology, 2004
Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures Proteins, 2003