Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol

2 Na+ + bile salts and acids → 2 Na+ + bile salts and acids

Reactome: R-HSA-194121
Compartment: plasma membrane
Rhea: None recorded

Inputs

2 Na+CHEBI:29101, Na, extracellular region
bile salts and acidsR-ALL-192483, extracellular region

Outputs

2 Na+CHEBI:29101, Na, cytosol
bile salts and acidsR-ALL-194156, cytosol

Catalysed by

bile acid:sodium symporter activity of SLC10A1 [plasma membrane]UniProt Q14973

Literature

Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter J Clin Invest, 1994