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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP21A2 oxidises 17HPROG

17aHPROG + NADPH + H+ + O2 → 11-deoxycortisol + NADP+ + H2O

Reactome: R-HSA-193981
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:50309

Inputs

17aHPROGCHEBI:17252, C21H30O3, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

11-deoxycortisolCHEBI:28324, C21H30O4, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

progesterone 21-hydroxylase activity of CYP21A2 [endoplasmic reticulum membrane]UniProt P08686

Literature

Structure of human steroid 21-hydroxylase genes Proc Natl Acad Sci U S A, 1986
Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia EMBO J, 1987