Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one
CHOL7a,24(S)DIOL + NAD+ → 4CHOL7a,24(S)DONE + NADH + H+
- Reactome
- R-HSA-193789
- Compartment
- cytosol · endoplasmic reticulum membrane
- Rhea
- RHEA:47200, RHEA:47201
Inputs
- CHOL7a,24(S)DIOLCHEBI:37640, C27H46O3, endoplasmic reticulum membrane
- NAD+CHEBI:57540, C21H26N7O14P2, cytosol
Outputs
- 4CHOL7a,24(S)DONECHEBI:63838, C27H44O3, endoplasmic reticulum membrane
- NADHCHEBI:57945, C21H27N7O14P2, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of HSD3B7 [endoplasmic reticulum membrane]EC 1.1.1; UniProt Q9H2F3
Literature
- Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease J Clin Endocrinol Metab, 2003
- The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis J Clin Invest, 2000