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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

3,7,24THCA-CoA is translocated from the cytosol to the peroxisome

3,7,24THCA-CoA + ATP + H2O → 3,7,24THCA-CoA + ADP + H+ + Pi

Reactome: R-HSA-193753
Compartment: cytosol · peroxisomal matrix · peroxisomal membrane
Rhea: None recorded

Inputs

3,7,24THCA-CoACHEBI:27403, C48H80N7O20P3S, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

3,7,24THCA-CoACHEBI:27403, C48H80N7O20P3S, peroxisomal matrix
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

ATPase-coupled transmembrane transporter activity of ABCD3 dimer [peroxisomal membrane]EC 7.2.2

Literature

A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3 Hum Mol Genet, 2015
Live cell FRET microscopy: homo- and heterodimerization of two human peroxisomal ABC transporters, the adrenoleukodystrophy protein (ALDP, ABCD1) and PMP70 (ABCD3) J Biol Chem, 2007
The enzymes, regulation, and genetics of bile acid synthesis Annu Rev Biochem, 2003
ATP-dependent transport of bile acid intermediates across rat liver peroxisomal membranes J Biochem (Tokyo), 2003