3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)
3,7,24THCA + ATP + CoA-SH → 3,7,24THCA-CoA + AMP + PPi + H2O
- Reactome
- R-HSA-193743
- Compartment
- cytosol · endoplasmic reticulum membrane
- Rhea
- None recorded
Inputs
- 3,7,24THCACHEBI:48736, C27H46O5, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
- CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
Outputs
- 3,7,24THCA-CoACHEBI:27403, C48H80N7O20P3S, cytosol
- AMPCHEBI:456215, C10H12N5O7P, cytosol
- PPiCHEBI:33019, HO7P2, cytosol
- H2OCHEBI:15377, H2O, cytosol
Catalysed by
- long-chain fatty acid-CoA ligase activity of SLC27A2 [endoplasmic reticulum membrane]EC 6.2.1.3; UniProt O14975
Literature
- Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein Mol Genet Metab, 1999
- The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase J Biol Chem, 2000
- Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling J Biol Chem, 2002