Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

3a,7a-dihydroxy-5b-cholest-24-one-CoA + CoA-SH → chenodeoxycholoyl-CoA + propionyl CoA

Reactome

R-HSA-193533

Compartment

peroxisomal matrix

Rhea

None recorded

Catalysed by

• propanoyl-CoA C-acyltransferase activity of SCP2-1 [peroxisomal matrix]EC 2.3.1.176; UniProt P22307

Literature

1. Cloning and expression of a cDNA encoding human sterol carrier protein 2 Proc Natl Acad Sci U S A, 1991
2. Peroxisomal fatty acid oxidation disorders and 58 kDa sterol carrier protein X (SCPx). Activity measurements in liver and fibroblasts using a newly developed method. J Lipid Res, 2000