(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA
3,7,24THCA-CoA + NAD+ → 3a,7a-dihydroxy-5b-cholest-24-one-CoA + NADH + H+
- Reactome
- R-HSA-193508
- Compartment
- peroxisomal matrix
- Rhea
- RHEA:47405
Inputs
- 3,7,24THCA-CoACHEBI:27403, C48H80N7O20P3S, peroxisomal matrix
- NAD+CHEBI:57540, C21H26N7O14P2, peroxisomal matrix
Outputs
- 3a,7a-dihydroxy-5b-cholest-24-one-CoACHEBI:87704, C48H74N7O20P3S, peroxisomal matrix
- NADHCHEBI:57945, C21H27N7O14P2, peroxisomal matrix
- H+CHEBI:15378, H, peroxisomal matrix
Catalysed by
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of HSD17B4 dimer [peroxisomal matrix]EC 1.1.1