(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA
(24R, 25R) 3a,7a,12a,24-tetrahydroxy-5b-cholestanoyl-CoA + NAD+ → 3a,7a,12a-trihydroxy-5b-cholest-24-one-CoA + NADH + H+
- Reactome
- R-HSA-193455
- Compartment
- peroxisomal matrix
- Rhea
- RHEA:47089, RHEA:47088
Inputs
- (24R, 25R) 3a,7a,12a,24-tetrahydroxy-5b-cholestanoyl-CoACHEBI:59807, C48H76N7O21P3S, peroxisomal matrix
- NAD+CHEBI:57540, C21H26N7O14P2, peroxisomal matrix
Outputs
- 3a,7a,12a-trihydroxy-5b-cholest-24-one-CoACHEBI:58507, C48H74N7O21P3S, peroxisomal matrix
- NADHCHEBI:57945, C21H27N7O14P2, peroxisomal matrix
- H+CHEBI:15378, H, peroxisomal matrix
Catalysed by
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of HSD17B4 dimer [peroxisomal matrix]EC 1.1.1
Literature
- Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase J Biochem (Tokyo), 1996
- Peroxisomal fatty acid oxidation disorders and 58 kDa sterol carrier protein X (SCPx). Activity measurements in liver and fibroblasts using a newly developed method. J Lipid Res, 2000