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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA

25(R) DHCA-CoA → 25(S) DHCA-CoA

Reactome: R-HSA-193452
Compartment: peroxisomal matrix
Rhea: None recorded

Inputs

25(R) DHCA-CoACHEBI:15494, C48H80N7O19P3S, peroxisomal matrix

Outputs

25(S) DHCA-CoACHEBI:15494, C48H80N7O19P3S, peroxisomal matrix

Catalysed by

racemase and epimerase activity of AMACR [peroxisomal matrix]EC 5.1; UniProt Q9UHK6

Literature

Purification and characterization of an alpha-methylacyl-CoA racemase from human liver Eur J Biochem, 1995
Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans J Lipid Res, 2000
Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy Nat Genet, 2000