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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Hydrolysis of choloyl-CoA to cholate and CoASH

H2O + choloyl-CoA → CCA + CoA-SH + H+

Reactome: R-HSA-193385
Compartment: peroxisomal matrix
Rhea: RHEA:14542

Inputs

H2OCHEBI:15377, H2O, peroxisomal matrix
choloyl-CoACHEBI:57373, C45H70N7O20P3S, peroxisomal matrix

Outputs

CCACHEBI:29747, C24H39O5, peroxisomal matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, peroxisomal matrix
H+CHEBI:15378, H, peroxisomal matrix

Catalysed by

choloyl-CoA hydrolase activity of ACOT8 [peroxisomal matrix]EC 3.1.2.27; UniProt O14734

Literature

Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism J Biol Chem, 2002
Identification of peroxisomal acyl-CoA thioesterases in yeast and humans J Biol Chem, 1999