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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ABCB11 transports bile salts from cytosol to extracellular region

bile salts + ATP + H2O → bile salts + ADP + Pi + H+

Reactome: R-HSA-193362
Compartment: plasma membrane
Rhea: RHEA:50056, RHEA:50052, RHEA:50064, RHEA:50060

Inputs

bile saltsR-ALL-193416, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

bile saltsR-ALL-193479, extracellular region
ADPCHEBI:456216, C10H12N5O10P2, cytosol
PiCHEBI:43474, HO4P, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

ABC-type bile acid transporter activity of ABCB11 [plasma membrane]UniProt O95342

Literature

Functional expression of the canalicular bile salt export pump of human liver Gastroenterology, 2002
The human bile salt export pump: characterization of substrate specificity and identification of inhibitors Gastroenterology, 2002