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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP19A1 hydroxylates TEST to EST17b

TEST + NADPH + H+ + O2 → EST17b + NADP+ + HCOOH + H2O

Reactome: R-HSA-193143
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

TESTCHEBI:17347, C19H28O2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

EST17bCHEBI:16469, C18H24O2, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
HCOOHCHEBI:15740, CHO2, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

steroid hydroxylase activity of CYP19A1 [endoplasmic reticulum membrane]UniProt P11511

Literature

Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis Endocr Rev, 1994
Structural and functional characterization of human aromatase P-450 gene Eur J Biochem, 1990