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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP17A1 cleaves 17aHPROG to ANDST

17aHPROG + O2 + NADPH + H+ → ANDST + NADP+ + H2O + CH3CHO

Reactome: R-HSA-193099
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

17aHPROGCHEBI:17252, C21H30O3, cytosol
O2CHEBI:15379, O2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

ANDSTCHEBI:16422, C19H26O2, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
H2OCHEBI:15377, H2O, cytosol
CH3CHOCHEBI:15343, C2H4O, cytosol

Catalysed by

steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]EC 1.14.14.19; UniProt P05093

Literature

Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations Mol Endocrinol, 1999