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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST

NAD+ + DHEA → ANDST + NADH + H+

Reactome: R-HSA-193073
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

NAD+CHEBI:57540, C21H26N7O14P2, cytosol
DHEACHEBI:28689, C19H28O2, cytosol

Outputs

ANDSTCHEBI:16422, C19H26O2, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

steroid Delta-isomerase activity of HSD3B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]EC 5.3.3.1

Literature

Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells J Biol Chem, 1990
A critical review of the origin and control of adrenal androgens Baillieres Clin Obstet Gynaecol, 1997