CYP17A1 cleaves 17aHPREG to DHA
17aHPREG + O2 + NADPH + H+ → NADP+ + H2O + CH3CHO + DHEA
- Reactome
- R-HSA-193070
- Compartment
- cytosol · endoplasmic reticulum membrane
- Rhea
- None recorded
Inputs
- 17aHPREGCHEBI:28750, C21H32O3, cytosol
- O2CHEBI:15379, O2, cytosol
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
- H+CHEBI:15378, H, cytosol
Outputs
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
- H2OCHEBI:15377, H2O, cytosol
- CH3CHOCHEBI:15343, C2H4O, cytosol
- DHEACHEBI:28689, C19H28O2, cytosol
Catalysed by
- steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]EC 1.14.14.19; UniProt P05093
Literature
- Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations Mol Endocrinol, 1999
- A critical review of the origin and control of adrenal androgens Baillieres Clin Obstet Gynaecol, 1997