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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HSD17B3-like proteins reducde ANDST to TEST

ANDST + NADPH + H+ → TEST + NADP+

Reactome: R-HSA-193064
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:14983

Inputs

ANDSTCHEBI:16422, C19H26O2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

TESTCHEBI:17347, C19H28O2, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

testosterone dehydrogenase (NADP+) activity of HSD17B3-like Proteins [endoplasmic reticulum membrane]EC 1.1.1.64

Literature

Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase Ann N Y Acad Sci, 1990
Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition J Steroid Biochem Mol Biol, 1995
Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3 Nat Genet, 1994
A critical review of the origin and control of adrenal androgens Baillieres Clin Obstet Gynaecol, 1997