Pregn-5-ene-3,20-dione isomerizes to progesterone

pregn-5-ene-3,20-dione → P4

Reactome

R-HSA-193052

Compartment

cytosol · endoplasmic reticulum membrane

Rhea

RHEA:43929

Catalysed by

• steroid Delta-isomerase activity of HSD3B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]EC 5.3.3.1

Literature

1. Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells J Biol Chem, 1990
2. Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes J Steroid Biochem, 1989
3. Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads Mol Endocrinol, 1991
4. Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase J Biol Chem, 2003