Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

3a,7a,12a-trihydroxy-5b-cholest-24-one-CoA + CoA-SH → choloyl-CoA + propionyl CoA

Reactome

R-HSA-192341

Compartment

peroxisomal matrix

Rhea

RHEA:16867

Catalysed by

• propanoyl-CoA C-acyltransferase activity of SCP2-1 [peroxisomal matrix]EC 2.3.1.176; UniProt P22307

Literature

1. Cloning and expression of a cDNA encoding human sterol carrier protein 2 Proc Natl Acad Sci U S A, 1991
2. Peroxisomal fatty acid oxidation disorders and 58 kDa sterol carrier protein X (SCPx). Activity measurements in liver and fibroblasts using a newly developed method. J Lipid Res, 2000