25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)
25(S) THCA-CoA + O2 → THCA-CoA + H2O2
- Reactome
- R-HSA-192335
- Compartment
- peroxisomal matrix
- Rhea
- RHEA:46729
Inputs
- 25(S) THCA-CoACHEBI:77251, C48H76N7O20P3S, peroxisomal matrix
- O2CHEBI:15379, O2, peroxisomal matrix
Outputs
- THCA-CoACHEBI:59879, C48H74N7O20P3S, peroxisomal matrix
- H2O2CHEBI:16240, H2O2, peroxisomal matrix
Catalysed by
- acyl-CoA oxidase activity of ACOX2:FAD [peroxisomal matrix]EC 1.3.3.6
Literature
- Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome Proc Natl Acad Sci U S A, 1996
- The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney J Biol Chem, 1993