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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

THCA-CoA + H2O → (24R, 25R) 3a,7a,12a,24-tetrahydroxy-5b-cholestanoyl-CoA

Reactome: R-HSA-192331
Compartment: peroxisomal matrix
Rhea: RHEA:18935

Inputs

THCA-CoACHEBI:59879, C48H74N7O20P3S, peroxisomal matrix
H2OCHEBI:15377, H2O, peroxisomal matrix

Outputs

(24R, 25R) 3a,7a,12a,24-tetrahydroxy-5b-cholestanoyl-CoACHEBI:59807, C48H76N7O21P3S, peroxisomal matrix

Catalysed by

3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity of HSD17B4 dimer [peroxisomal matrix]EC 4.2.1.107

Literature

Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase J Biochem (Tokyo), 1996