Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate

choloyl-CoA + Gly, TAU → cholate bile salts + CoA-SH + H+

Reactome: R-HSA-192312
Compartment: peroxisomal matrix
Rhea: RHEA:47101, RHEA:14002

Inputs

choloyl-CoACHEBI:57373, C45H70N7O20P3S, peroxisomal matrix
Gly, TAUR-ALL-193463, peroxisomal matrix

Outputs

cholate bile saltsR-ALL-193404, peroxisomal matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, peroxisomal matrix
H+CHEBI:15378, H, peroxisomal matrix

Catalysed by

acyltransferase activity, transferring groups other than amino-acyl groups of BAAT [peroxisomal matrix]EC 2.3.1; UniProt Q14032

Literature

Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. J Biol Chem, 1994