7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
7 alpha-hydroxycholesterol + NAD+ → 4CHOL7aOLONE + NADH + H+
- Reactome
- R-HSA-192097
- Compartment
- cytosol · endoplasmic reticulum membrane
- Rhea
- RHEA:11896
Inputs
- 7 alpha-hydroxycholesterolCHEBI:17500, C27H46O2, endoplasmic reticulum membrane
- NAD+CHEBI:57540, C21H26N7O14P2, cytosol
Outputs
- 4CHOL7aOLONECHEBI:17899, C27H44O2, endoplasmic reticulum membrane
- NADHCHEBI:57945, C21H27N7O14P2, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of HSD3B7 [endoplasmic reticulum membrane]EC 1.1.1; UniProt Q9H2F3
Literature
- Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease J Clin Endocrinol Metab, 2003
- The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis J Clin Invest, 2000