Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one

4CHOL7a,12aDONE + NADPH + H+ → 5beta-cholesten-7alpha, 12alpha-diol-3-one + NADP+

Reactome: R-HSA-192067
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:46632, RHEA:46633

Inputs

4CHOL7a,12aDONECHEBI:28477, C27H44O3, endoplasmic reticulum membrane
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

5beta-cholesten-7alpha, 12alpha-diol-3-oneCHEBI:2288, C27H46O3, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

alcohol dehydrogenase (NADP+) activity of AKR1D1 [cytosol]EC 1.1.1.2; UniProt P51857

Literature

Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme Eur J Biochem, 1994