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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Cholesterol is hydroxylated to 25-hydroxycholesterol

CHOL + NADPH + H+ + O2 → H2O + NADP+ + 25OH-CHOL

Reactome: R-HSA-191983
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:46133

Inputs

CHOLCHEBI:16113, C27H46O, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

H2OCHEBI:15377, H2O, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
25OH-CHOLCHEBI:42977, C27H46O2, cytosol

Catalysed by

steroid hydroxylase activity of CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane]

Literature

cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism J Biol Chem, 1998