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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Mevalonate-5-phosphate is further phosphorylated

MVA5P + ATP → MVA5PP + ADP

Reactome: R-HSA-191422
Compartment: cytosol
Rhea: RHEA:16342

Inputs

MVA5PCHEBI:58146, C6H10O7P, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

MVA5PPCHEBI:57557, C6H10O10P2, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol

Catalysed by

phosphomevalonate kinase activity of PMVK [cytosol]EC 2.7.4.2; UniProt Q15126

Literature

Phosphomevalonate kinase: functional investigation of the recombinant human enzyme Biochemistry, 2006
Phosphomevalonate kinase is a cytosolic protein in humans J Lipid Res, 2004