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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Reduction of presqualene diphosphate to form squalene

PSQPP + H+ + NADPH → SQNE + NADP+ + PPi

Reactome: R-HSA-191402
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:22233

Inputs

PSQPPCHEBI:57310, C30H49O7P2, cytosol
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Outputs

SQNECHEBI:15440, C30H50, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

squalene synthase [NAD(P)H] activity of FDFT:Mg2+ [endoplasmic reticulum membrane]EC 2.5.1.21

Literature

Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis. J Biol Chem, 2000