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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Mevalonate is phosphorylated to mevalonate-5-phosphate

MVA + ATP → MVA5P + ADP + H+

Reactome: R-HSA-191380
Compartment: cytosol
Rhea: RHEA:17066

Inputs

MVACHEBI:36464, C6H11O4, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

MVA5PCHEBI:58146, C6H10O7P, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

mevalonate kinase activity of MVK dimer [cytosol]EC 2.7.1.36

Literature

Mevalonate kinase is a cytosolic enzyme in humans J Cell Sci, 2004
Biochemical and genetic aspects of mevalonate kinase and its deficiency Biochim Biophys Acta, 2000
Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria J Biol Chem, 1992