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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Squalene 2,3-epoxide cyclizes, forming lanosterol

SQOX → LAN

Reactome: R-HSA-191366
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:14621, RHEA:14622

Inputs

SQOXCHEBI:15441, C30H50O, cytosol

Outputs

LANCHEBI:16521, C30H50O, endoplasmic reticulum membrane

Catalysed by

lanosterol synthase activity of LSS [endoplasmic reticulum membrane]EC 5.4.99.7; UniProt P48449

Literature

The monotopic membrane protein human oxidosqualene cyclase is active as monomer Biochem Biophys Res Commun, 2004
Molecular cloning of cDNA encoding human lanosterol synthase Biol Pharm Bull, 1995
Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol J Am Chem Soc, 1966