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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HMGCR dimer reduces bHMG-CoA to MVA

bHMG-CoA + 2 NADPH + 2 H+ → MVA + CoA-SH + 2 NADP+

Reactome: R-HSA-191352
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:15991

Inputs

bHMG-CoACHEBI:43074, C27H39N7O20P3S, cytosol
2 NADPHCHEBI:57783, C21H26N7O17P3, cytosol
2 H+CHEBI:15378, H, cytosol

Outputs

MVACHEBI:36464, C6H11O4, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
2 NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

hydroxymethylglutaryl-CoA reductase (NADPH) activity of HMGCR dimer [endoplasmic reticulum membrane]EC 1.1.1.34

HMGCR dimer reduces bHMG-CoA to MVA

Inputs

Outputs

Catalysed by

Literature