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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA

Ac-CoA + ACA-CoA + H2O → CoA-SH + bHMG-CoA + H+

Reactome: R-HSA-191323
Compartment: cytosol
Rhea: RHEA:10189

Inputs

Ac-CoACHEBI:57288, C23H34N7O17P3S, cytosol
ACA-CoACHEBI:57286, C25H36N7O18P3S, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
bHMG-CoACHEBI:43074, C27H39N7O20P3S, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

hydroxymethylglutaryl-CoA synthase activity of HMGCS1 [cytosol]EC 2.3.3.10; UniProt Q01581

Literature

Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes Arch Biochem Biophys, 1994