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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FDPS dimer transfers IPPP to DMAPP

DMAPP + IPPP → GPP + PPi

Reactome: R-HSA-191322
Compartment: cytosol
Rhea: RHEA:22409

Inputs

DMAPPCHEBI:57623, C5H9O7P2, cytosol
IPPPCHEBI:128769, C5H9O7P2, cytosol

Outputs

GPPCHEBI:58057, C10H17O7P2, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

dimethylallyltranstransferase activity of holo-FDPS dimer [cytosol]EC 2.5.1.1

Literature

Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. J Biol Chem, 1999
Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression J Lipid Res, 1998
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs Proc Natl Acad Sci U S A, 2006
Structure, catalysis, and inhibition mechanism of prenyltransferase IUBMB Life, 2021