Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

S2P hydrolyzes SREBP1A,1C,2

SREBF1A,1C,2 cleaved by S1P → SREBF1A,1C,2 cleaved by S2P

Reactome: R-HSA-1655851
Compartment: Golgi membrane · cytosol
Rhea: None recorded

Inputs

SREBF1A,1C,2 cleaved by S1PR-HSA-1655726, Golgi membrane

Outputs

SREBF1A,1C,2 cleaved by S2PR-HSA-1655732, cytosol

Catalysed by

metalloendopeptidase activity of MBTPS2 [Golgi membrane]EC 3.4.24.11; UniProt O43462

S2P hydrolyzes SREBP1A,1C,2

Inputs

Outputs

Catalysed by

Literature