S1P hydrolyzes SREBP1A,1C,2

SREBP1A,1C,2:SCAP → SCAP tetramer + 4 SREBF1A,1C,2 cleaved by S1P

Reactome

R-HSA-1655842

Compartment

Golgi membrane

Rhea

None recorded

Catalysed by

• serine-type endopeptidase activity of MBTPS1 [Golgi membrane]EC 3.4.21.1; UniProt Q14703

Literature

1. Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment J Biol Chem, 2000
2. Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells J Nutr, 2007
3. Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins J Biol Chem, 1999
4. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment Cell, 1996
5. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis Cell, 1994
6. Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies J Biol Chem, 1998