SREBP1A,1C,2 translocates to the nucleus
SREBP1A,1C,2:Importin beta-1 → SREBP1A,1C,2:Importin beta-1
- Reactome
- R-HSA-1655831
- Compartment
- cytosol · nucleoplasm
- Rhea
- None recorded
Inputs
- SREBP1A,1C,2:Importin beta-1R-HSA-2065556, cytosol
Outputs
- SREBP1A,1C,2:Importin beta-1R-HSA-2065543, nucleoplasm
Literature
- SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis Cell, 1994
- Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment Cell, 1996
- Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta Mol Cell Biol, 2001
- The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor Science, 2003
- Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip Mol Biol Cell, 1999
- Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution Structure, 1998