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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ARSC hydrolyzes steroid sulfates

H2O + steroid sulfate → SO4(2-) + steroid

Reactome: R-HSA-1606839
Compartment: endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
steroid sulfateCHEBI:59696, endoplasmic reticulum lumen

Outputs

SO4(2-)CHEBI:16189, O4S, endoplasmic reticulum lumen
steroidCHEBI:35341, C19H31R, endoplasmic reticulum lumen

Catalysed by

steryl-sulfatase activity of active STS dimer [endoplasmic reticulum membrane]EC 3.1.6.2

Literature

Human placental steroid sulfatase: purification and properties J Steroid Biochem, 1983
Purification and properties of steroid sulfatase from human placenta Endocrinol Jpn, 1992
Purification and properties of arylsulfatase C from human placenta Enzyme, 1987
Cloning and expression of human steroid-sulfatase. Membrane topology, glycosylation, and subcellular distribution in BHK-21 cells J Biol Chem, 1989
Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis Am J Hum Genet, 1992
Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein J Biol Chem, 1997