Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine
choloyl-CoA; chenodeoxycholoyl-CoA + Gly, TAU → bile salts + CoA-SH
- Reactome
- R-HSA-159431
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- choloyl-CoA; chenodeoxycholoyl-CoAR-ALL-194073, cytosol
- Gly, TAUR-ALL-194069, cytosol
Outputs
- bile saltsR-ALL-193416, cytosol
- CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
Catalysed by
- acyltransferase activity of BAAT [cytosol]EC 2.3; UniProt Q14032
Literature
- Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. J Biol Chem, 1994
- Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver J Biol Chem, 1991
- Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts J Lipid Res, 2000