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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)

CCA,CDCA + ATP + CoA-SH → choloyl-CoA; chenodeoxycholoyl-CoA + AMP + PPi + H2O

Reactome: R-HSA-159425
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

CCA,CDCAR-ALL-194096, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Outputs

choloyl-CoA; chenodeoxycholoyl-CoAR-ALL-194073, cytosol
AMPCHEBI:456215, C10H12N5O7P, cytosol
PPiCHEBI:33019, HO7P2, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

long-chain fatty acid-CoA ligase activity of SLC27A5 [endoplasmic reticulum membrane]EC 6.2.1.3; UniProt Q9Y2P5

Literature

Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling J Biol Chem, 2002