Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Carbonic anhydrase dehydrates bicarbonate (mitochondria)

H+ + HCO3- → CO2 + H2O

Reactome: R-HSA-1475028
Compartment: mitochondrial matrix
Rhea: RHEA:10749

Inputs

H+CHEBI:15378, H, mitochondrial matrix
HCO3-CHEBI:17544, CHO3, mitochondrial matrix

Outputs

CO2CHEBI:16526, CO2, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix

Catalysed by

carbonate dehydratase activity of CA5A,B:Zinc [mitochondrial matrix]EC 4.2.1.1

Literature

Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors J Med Chem, 2005
Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anions Bioorg Med Chem Lett, 2003
Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different Bioorg Med Chem, 2007
Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome x J Biol Chem, 1999
Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16 Proc Natl Acad Sci U S A, 1993
Structure and mechanism of carbonic anhydrase Pharmacol Ther, 1997