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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Carbonic anhydrase dehydrates bicarbonate (cytosol)

H+ + HCO3- → CO2 + H2O

Reactome: R-HSA-1475022
Compartment: cytosol
Rhea: RHEA:10749

Inputs

H+CHEBI:15378, H, cytosol
HCO3-CHEBI:17544, CHO3, cytosol

Outputs

CO2CHEBI:16526, CO2, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

carbonate dehydratase activity of CA1,2,3,7,13:Zinc [cytosol]EC 4.2.1.1

Literature

The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C J Biol Chem, 1971
A 13C nuclear magnetic resonance study of CO2/HCO-3 exchange catalyzed by human carbonic anhydrase I Eur J Biochem, 1982
Buffer dependence of CO2 hydration catalyzed by human carbonic anhydrase I Biochim Biophys Acta, 1992
Structure and mechanism of carbonic anhydrase Pharmacol Ther, 1997
Anion inhibition of CO2 hydration catalyzed by human carbonic anhydrase II. Mechanistic implications Biochim Biophys Acta, 1984
A chemical and enzymological comparison of the common major human erythrocyte carbonic anhydrase II, its minor component, and a new genetic variant, CA II Melbourne (237 Pro leads to His) Hum Genet, 1983