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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Carbonic anhydrase dehydrates bicarbonate (plasma membrane)

H+ + HCO3- → CO2 + H2O

Reactome: R-HSA-1475017
Compartment: plasma membrane · extracellular region
Rhea: RHEA:10749

Inputs

H+CHEBI:15378, H, extracellular region
HCO3-CHEBI:17544, CHO3, extracellular region

Outputs

CO2CHEBI:16526, CO2, extracellular region
H2OCHEBI:15377, H2O, extracellular region

Catalysed by

carbonate dehydratase activity of CA4,9,14,12:Zn2+ [plasma membrane]EC 4.2.1.1

Literature

Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney J Biol Chem, 1990
Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity Arch Biochem Biophys, 1995
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions Bioorg Med Chem Lett, 2004
Catalysis and inhibition of human carbonic anhydrase IV Biochemistry, 1997
Structure and mechanism of carbonic anhydrase Pharmacol Ther, 1997
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes J Biol Chem, 2008