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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Corticosteroids bind to CBG in blood

SERPINA6 + Corticosteroids → CBG:Corticosteroids

Reactome: R-HSA-1449687
Compartment: extracellular region
Rhea: None recorded

Inputs

SERPINA6R-HSA-1449658, extracellular region
CorticosteroidsR-ALL-1449707, extracellular region

Outputs

CBG:CorticosteroidsR-HSA-1449677, extracellular region

Catalysed by

molecular carrier activity of SERPINA6 [extracellular region]UniProt P08185

Literature

Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors Proc Natl Acad Sci U S A, 1987
Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma J Clin Endocrinol Metab, 1981